Gilman reagent toward the synthesis of natural products.

With the ever-increasing scope of organocuprates, a well-established Gilman reagent has been considered as an unprecedented synthetic tool in modern organic chemistry. The broad research profile of the Gilman reagent (R2CuLi in THF or Et2O) is owing to its propensity to carry out three kinds of reactions, i.e., epoxide ring opening reactions, 1,4-conjugate addition reactions, and SN2 reactions in a regioselective manner. This review examines the applications of Gilman reagent in the total synthesis of both abundant and scarce natural products of remarkable synthetic pharmaceutical profile reported since 2011. The presented insights will be of a vital roadmap to general organic synthesis and it will contribute to the development of new natural products and their analogues in future drug discovery.

Simmons-Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review.

Simmons-Smith cyclopropanation is a widely used reaction in organic synthesis for stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be realized by the fact that the cyclopropane motif is a privileged synthetic intermediate and a core structural unit of many biologically active natural compounds such as terpenoids, alkaloids, nucleosides, amino acids, fatty acids, polyketides and drugs. The modified form of Simmons-Smith cyclopropanation involves the employment of Et2Zn and CH2I2 (Furukawa reagent) toward the total synthesis of a variety of structurally complex natural products that possess broad range of biological activities including anticancer, antimicrobial and antiviral activities. This review aims to provide an intriguing glimpse of the Furukawa-modified Simmons-Smith cyclopropanation, within the year range of 2005 to 2022.

Flood in mountainous communities of Pakistan: how does it shape the livelihood and economic status and government support?

The agriculture sector remains under attack by the consistent flooding events in Pakistan as flooding water is sweeping away crops and livelihood opportunities, thus dragging the already vulnerable communities into poverty. This research has studied the adverse impacts of consistent floods (2010 to 2018) on the rural mountainous agriculture, agrarian occupation, economic system, and rise in poverty in ten districts of Hazara and Malakand divisions, Khyber-Pakhtunkhwa province, Pakistan. In total, 1000 self-administered questionnaires were deployed at the household level through judgment sampling studying the flood-affected households. Primary data for the impacts of floods on the livelihood, economic status, and poverty and correlation among them was estimated through three parallel logistic regression equations based on indexes for three separate models for the study variable to describe the flood-induced vulnerability at HH level. The results of the interrelationship of the selected variables declared Malakand division more prone to loss of livelihood, degradation of low-economic status, and increased in poverty due to flooding than Hazara division. It is concluded that floods have curtailed the agricultural livelihood on damaging crop production that has degraded locals' economic system by reducing household's income and savings, ending up in borrowing of money and leading to debt due to non-repayment. Households' vulnerability has increased due to increased poverty as being more exposed to natural disasters. It calls for government intervention to safeguard poor mountainous communities of Pakistan through financial help, seeds, livestock, and technical help in times of disaster.